The Early Pleistocene Lake ‘Ubeidiya (south Levantine Corridor) is known as a pivotal site of global importance as its sedimentary record hosts hominin skeletal remains, lithics, and extensive faunal assemblages. For the first time, a sediment core was retrieved from the ‘Ubeidiya Formation providing a valuable ground for carrying out high-resolution studies with the aim to fill the knowledge gap on the environmental conditions characterizing the region ~1.5 Ma. A high-resolution study was done in the ~15.9 m long core by measuring physical (grain size), chemical (elemental geochemistry), and biological (macrofaunal assemblages) properties, allowing the reconstruction the lake response to climate variability and hydrological changes. Moreover, the amalgamation of analytical techniques provided valuable insights into the paleolimnological conditions, including reconstructing lake-mixing regimes and unraveling the potential interconnectivity with other lake basins. Our analyses show extreme fluctuations in the lake environment at shorter time scales than previously addressed. Moreover, the study shows that the lake transitioned from a monomictic and eutrophic state (with regularly mixed hypolimnion), to meromictic conditions (characterized by continuous anoxia in the deep-water layer), and finalized with a well-mixed, oligotrophic shallow lake system that deposited evaporite sediments. The results of this study show suggest that early hominins may have survived and sustained near lakes with a wide range of limnic conditions and water chemistries and set the ground for further high-resolution studies.